Genomic Characterization of Adaptive Mutations that Effect Minimal Fitness Trade-offs in Evolved Clones of Saccharomyces cerevisiae

ABSTRACT: In some of the earliest uses of genome-wide gene-expression microarrays and array-based Comparative Genomic Hybridization (aCGH), a set of diploid yeasts that had undergone experimental evolution under aerobic glucose limitation was used to explore how gene expression and genome structure had responded to this selection pressure. To more deeply understand how adaptation to one environment might constrain or enhance performance in another we have now identified the adaptive mutations in this set of clones using whole-genome sequencing, and have assessed whether the evolved clones had become generalists or specialists by assaying their fitness under three contrasting growth environments: aerobic and anaerobic glucose limitation and aerobic acetate limitation. Additionally, evolved clones and

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Jared Wenger 

PROVIDER: E-GEOD-25081 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress