Regulation of gene expression in ALK inhibitor CH5424802-treated NCI-H2228 xenograft tumors

ABSTRACT: To clarify the downstream signal pathway of EML4-ALK in NSCLC, we performed Affymetrix GeneChip analysis using ALK inhibitor CH5424802-treated NCI-H2228 xenograft tumors, and comprehensively characterized the gene expression regulated by inhibition of activated ALK. Mice bearing NCI-H2228 cells were orally administered at dose of 0 (vehicle), 4 or 20 mg/kg of CH5424802, and the tumors were collected and lysed at 6 hours post-dose. Total RNA were extracted from xenograft tumors.

ORGANISM(S): Mus musculus

SUBMITTER: Hiroshi Sakamoto 

PROVIDER: E-GEOD-25118 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress