Optimizing molecular signatures for prostate cancer recurrence

ABSTRACT: The derivation of molecular signatures indicative of disease status and predictive of subsequent behavior could facilitate the optimal choice of treatment for prostate cancer patients. In this study, we conducted a computational analysis of gene expression profile data obtained from 79 cases, 39 of which were classified as having disease recurrence, to investigate whether advanced computational algorithms can derive more accurate prognostic signatures for prostate cancer. At the 90% sensitivity level, a newly derived prognostic genetic signature achieved 85% specificity. This is the first reported genetic signature to outperform a clinically used postoperative nomogram. Furthermore, a hybrid prognostic signature derived by combination of the nomogram and gene expression data significantly

ORGANISM(S): Homo sapiens

SUBMITTER: Steve Goodison 

PROVIDER: E-GEOD-25136 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress