Tracheal occlusion conditioning in conscious rats modulates gene expression profile of medial thalamus

ABSTRACT: The thalamus may be the critical brain area involved in sensory gating and the relay of respiratory mechanical information to the cerebral cortex for the conscious awareness of breathing. We hypothesized that respiratory mechanical stimuli in the form of tracheal occlusions would modulate the gene expression profile of the thalamus. Specifically, it was reasoned that conditioning to the respiratory loading would induce a state change in the medial thalamus consistent with a change in sensory gating and the activation of molecular pathways associated with learning and memory. In addition, respiratory loading is stressful and thus should elicit changes in gene expressions related to stress, anxiety, and depression. Rats were instrumented with inflatable tracheal cuffs. Following surgical rec

ORGANISM(S): Rattus norvegicus

SUBMITTER: Vipa Bernhardt 

PROVIDER: E-GEOD-25152 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress