PHK Cells: control vs. cyclosporine vs. 11R-VIVIT

ABSTRACT: Calcineurin/NFAT signaling pathway has been shown to play important roles in various tissues such as the immune system, cardiac muscle and neuron. Although recent studies have shown that the pathway is involved in the regulation of hair growth, the precise mechanism is still unclear. In this study, we examine the molecular mechanism which is regulated by calcineurin/NFAT pathway, using two specific inhibitors for the pathway. Transcriptional profiling of human keratinocyte cell line, PHK cells, comparing control untreated PHK cells with cyclosporin A (CsA)-treated or 11R-VIVIT-treated PHK cells. Goal was to identify the effects of NFAT inhibitors on PHK cell proliferation. Cyclosporine A is a chemical compound, which strongly inhibits calcineurin phosphatase activity cooperating with cyclo

ORGANISM(S): Homo sapiens

SUBMITTER: Atsushi Fujimura 

PROVIDER: E-GEOD-25175 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress