Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Non-canonical compensation of zygotic X transcription in Drosophila melanogaster development revealed through single embryo RNA-Seq

ABSTRACT: We sequenced mRNA from 24 single D. melanogaster embryos (12 male and 12 female) taken from 8 early embryonic timepoints to generate the first sex specific timecourse of gene expression in early Drosophila development Examination of mRNA levels in individual male and female embryos at 8 timepoints between the onset of zygotic transcription and gastrulation

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Michael Eisen 

PROVIDER: E-GEOD-25180 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Noncanonical compensation of zygotic X transcription in early Drosophila melanogaster development revealed through single-embryo RNA-seq.

Lott Susan E SE   Villalta Jacqueline E JE   Schroth Gary P GP   Luo Shujun S   Tonkin Leath A LA   Eisen Michael B MB  

PLoS biology 20110208 2

When Drosophila melanogaster embryos initiate zygotic transcription around mitotic cycle 10, the dose-sensitive expression of specialized genes on the X chromosome triggers a sex-determination cascade that, among other things, compensates for differences in sex chromosome dose by hypertranscribing the single X chromosome in males. However, there is an approximately 1 hour delay between the onset of zygotic transcription and the establishment of canonical dosage compensation near the end of mitot  ...[more]