Transcription levels in human colon biopsies in IBS and IBD patients before and after participating in a high red-meat dietary intervention

ABSTRACT: Study 1: Transcriptomic profiles in colon tissue from inflammatory bowel diseases patients in relation to N-nitroso compound exposure and colorectal cancer risk Study 1: N-nitroso compounds (NOC) have been suggested to play a role in human cancer development but definitive evidence is still lacking. In this study we investigated gene expression modifications induced in human colon tissue in relation to NOC exposure to gain insight in the relevance of these compounds in human colorectal cancer (CRC) development. Since there are indications that inflammation stimulates endogenous NOC formation, the study population consisted of patients with inflammatory bowel disease (IBD) and irritable bowel syndrome patients as controls without inflammation. Strong transcriptomic differences were identif

ORGANISM(S): Homo sapiens

SUBMITTER: Dennie Hebels 

PROVIDER: E-GEOD-25220 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress