Atlas of gene expression in the mouse kidney

ABSTRACT: To gain molecular insight into kidney function, we performed a high-resolution quantitative analysis of gene expression in glomeruli and nine different nephron seg-ments dissected from mouse kidney using the long-SAGE method. We also developed dedicated bioinformatics tools and databases to annotate mRNA tags as transcripts. Over 800,000 mRNA SAGE tags were sequenced corresponding to >20,000 different mRNA tags present at least twice in at least one library. Hierarchical clustering analysis of tags demonstrated similarities between the three anatomical sub-segments of the proximal tubule, between the cortical and medullary segments of the thick ascending limb of Henle’s loop, and between the three segments constituting the aldosterone sensitive distal nephron segments, whereas the glomerul

ORGANISM(S): Mus musculus

SUBMITTER: Lydie Cheval 

PROVIDER: E-GEOD-25223 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress