Extensive effects of in vitro oocyte maturation on rhesus monkey cumulus cell transcriptome

ABSTRACT: The elaboration of a quality oocyte is integrally linked to the correct developmental progression of cumulus cell phenotype. In humans and non-human primates, oocyte quality is diminished with in vitro maturation. To determine the changes in gene expression in rhesus monkey cumulus cells (CC) that occur during the final day prior to oocyte maturation and how these changes differ between in vitro and in vivo maturation (IVM and VVM), we completed a detailed comparison of transcriptomes using the Affymetrix gene array. We observe a large number of genes differing in expression when comparing IVM-CC and VVM-CC directly, but a much larger number of differences comparing the transitions from the pre-oocyte maturation to post- IVM and post-VVM state. We observe a truncation or delay in the norma

ORGANISM(S): Macaca mulatta

SUBMITTER: Young Lee 

PROVIDER: E-GEOD-25288 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress