Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Expression data from breast tumors and reduction mammoplasty explants

ABSTRACT: Breast tumorigenesis involves modulation of gene expression. We used microarrays to detail the global program of gene expression underlying breast tumorigenesis. Three examples of stage I breast tumor and 3 samples of breast reduction mammoplasty tissue were expanded as explant cultures for RNA extraction and hybridization to Affymetrix microarrays.

ORGANISM(S): Homo sapiens

SUBMITTER: Jean Latimer

PROVIDER: E-GEOD-25407 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Nucleotide excision repair deficiency is intrinsic in sporadic stage I breast cancer.

Latimer Jean J JJ Johnson Jennifer M JM Kelly Crystal M CM Miles Tiffany D TD Beaudry-Rodgers Kelly A KA Lalanne Nancy A NA Vogel Victor G VG Kanbour-Shakir Amal A Kelley Joseph L JL Johnson Ronald R RR Grant Stephen G SG

Proceedings of the National Academy of Sciences of the United States of America 20101130 50

The molecular etiology of breast cancer has proven to be remarkably complex. Most individual oncogenes are disregulated in only approximately 30% of breast tumors, indicating that either very few molecular alterations are common to the majority of breast cancers, or that they have not yet been identified. In striking contrast, we now show that 19 of 19 stage I breast tumors tested with the functional unscheduled DNA synthesis assay exhibited a significant deficiency of DNA nucleotide excision re ...[more]

PMID: 21118987

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Dataset Information

Expression data from breast tumors and reduction mammoplasty explants

Publications

Nucleotide excision repair deficiency is intrinsic in sporadic stage I breast cancer.

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