The pan-genome of the dominant human gut-associated archaeon, Methanobrevibacter smithii

ABSTRACT: The human gut microbiota harbors methanogens represented by the dominant archaeon, Methanobrevibacter smithii, a polyphyletic group of acetogens, and sulfate-reducing bacteria. Defining their roles in the H2-economy of the gut has potential therapeutic importance for modulating the efficiency of fermentation of dietary components. We quantified methanogens in fecal samples from 40 healthy adult female monozygotic(MZ) and 28 dizygotic(DZ) twin pairs, analyzed bacterial 16S rRNA datasets generated from their fecal samples to identify taxa that co-occur with methanogens, sequenced the genomes of 20 M. smithii strains isolated from families of MZ and DZ twins, and performed RNA-Seq of a subset of strains to identify their responses to varied formate concentrations. The concordance rate for me

ORGANISM(S): Methanobrevibacter smithii

SUBMITTER: Federico Rey 

PROVIDER: E-GEOD-25408 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress