Global regulation in response to sulfur availability in the cheese-related bacterium, Brevibacterium aurantiacum

ABSTRACT: In this study, we combined metabolic reconstruction, growth assays, metabolome and transcriptome analyses to obtain a global view of the sulfur metabolic network and of the response to sulfur availability in Brevibacterium aurantiacum. In agreement with the growth of B. aurantiacum in the presence of sulfate and cystine, the metabolic reconstruction showed the presence of a sulfate assimilation pathway and of thiolation pathways that produce cysteine (cysE and cysK) or homocysteine (metX and metY) from sulfide, of at least one gene of the transsulfuration pathway (aecD) and of genes encoding three MetE-type methionine synthases. We also compared the expression profiles of B. aurantiacum ATCC9175 during sulfur starvation and in the presence of sulfate, cystine or methionine plus cystine. In

ORGANISM(S): Brevibacterium aurantiacum

SUBMITTER: Marie-Pierre FORQUIN 

PROVIDER: E-GEOD-25422 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress