Elucidation of Zymomonas mobilis physiology and stress responses by quantitative proteomics and transcriptomics

ABSTRACT: Zymomonas mobilis is an excellent ethanologenic bacterium. Biomass pretreatment and saccharification provides access to simple sugars, but also produces inhibitors such as acetate and furfural. Our previous work has identified and confirmed the genetic change of a 1.5-kb deletion in the sodium acetate tolerant Z. mobilis mutant (AcR) leading to constitutively elevated expression of a sodium proton antiporter encoding gene nhaA, which contributes to the sodium acetate tolerance of AcR mutant. In this study, we further investigated the responses of AcR and wild-type ZM4 to sodium acetate stress in minimum media using both transcriptomics and a metabolic labeling approach for quantitative proteomics the first time. Proteomic measurements at two time points identified about eight hundreds prot

ORGANISM(S): Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821

SUBMITTER: Shihui YANG 

PROVIDER: E-GEOD-25443 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress