Global changes in Staphylococcus aureus gene expression in human blood provide insight into mechanisms of immune evasion and virulence

ABSTRACT: Staphylococcus aureus is a leading cause of bloodstream infections worldwide. In the United States, many of these infections are caused by a strain known as USA300. Although progress has been made, our understanding of the S. aureus molecules that promote bacteremia and survival in human blood is incomplete. To that end, we analyzed the USA300 transcriptome during culture in human blood, human serum, and trypticase soy broth (TSB), a standard laboratory culture media. Notably, genes encoding several cytolytic toxins were up-regulated in human blood over time, and hlgA, hlgB, and hlgC (encoding gamma-hemolysin subunits HlgA, HlgB, and HlgC) were among the most highly up-regulated genes at all time points. Culture supernatants derived from a USA300 isogenic hlgABC-deletion strain (LAC?hl

ORGANISM(S): Staphylococcus aureus

SUBMITTER: Dan Sturdevant 

PROVIDER: E-GEOD-25454 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress