A signature of 6 genes highlights defects on cell growth and specific metabolic pathways in murine and human hepatocellular carcinoma.

ABSTRACT: Hepatocellular carcinoma (HCC) represents a major health problem as it afflicts an increasing number of patients worldwide. Albeit most of the risk factors for HCC are known, this is a deadly syndrome with a life expectancy at the time of diagnosis of less than 1 year. Definition of the molecular principles governing the neoplastic transformation of the liver is an urgent need to facilitate the clinical management of patients, based on innovative methods to detect the disease in its early stages and on more efficient therapies. In the present study we have combined the analysis of a murine model and human samples of HCC to identify genes differentially expressed early in the process of hepatocarcinogenesis, using a microarray based approach. Expression of 190 genes was impaired in murine H

ORGANISM(S): Mus musculus

SUBMITTER: Paul SchrM-CM-6der 

PROVIDER: E-GEOD-25457 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress