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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Expression data from Adam10 knock out mice and wild type

ABSTRACT: Adam10, a cell surface protease, cleaving many proteins including TNF-alpha and E-cadherin. Here we investigate the genome wide effects of Adam10 knock out on the transcriptome. Commercial microarrays (Affymetrix Mouse Gene ST 1.0) were used to generate genome wide mRNA profiles. Mouse tissue samples from n=4 wiltype skin and n=4 Adam10 knockout skin were used in the study.

ORGANISM(S): Mus musculus

SUBMITTER: Robert Haesler

PROVIDER: E-GEOD-25480 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling.

Weber Silvio S Niessen Michaela T MT Prox Johannes J Lüllmann-Rauch Renate R Schmitz Annika A Schwanbeck Ralf R Blobel Carl P CP Jorissen Ellen E de Strooper Bart B Niessen Carien M CM Saftig Paul P

Development (Cambridge, England) 20110201 3

The disintegrin and metalloproteinase Adam10 has been implicated in the regulation of key signaling pathways that determine skin morphogenesis and homeostasis. To address the in vivo relevance of Adam10 in the epidermis, we have selectively disrupted Adam10 during skin morphogenesis and in adult skin. K14-Cre driven epidermal Adam10 deletion leads to perinatal lethality, barrier impairment and absence of sebaceous glands. A reduction of spinous layers, not associated with differences in either p ...[more]

PMID: 21205794

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