Transcription profiling of human malignant pleural mesothelioma tumors and cell lines

ABSTRACT: Malignant pleural mesothelioma (MPM) is a highly lethal, poorly understood neoplasm that is typically associated with asbestos exposure. We performed transcriptional profiling using high-density oligonucleotide microarrays containing approximately 22,000 genes to elucidate potential molecular and pathobiological pathways in MPM using discarded human MPM tumor specimens (n=40), normal lung specimens (n=4), normal pleura specimens (n=5), and MPM and SV40-immortalized mesothelial cell lines (n=5). In global expression analysis using unsupervised clustering techniques, we found two potential subclasses of mesothelioma which correlate loosely with tumor histology. We also identified sets of genes with expression levels that distinguish between multiple tumor subclasses, normal and tumor tissues

ORGANISM(S): Homo sapiens

DISEASE(S): normal

SUBMITTER: Gavin Gordon 

PROVIDER: E-GEOD-2549 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress