Autism and increased paternal age related changes in global levels of gene expression regulation

ABSTRACT: A causal role of mutations in genes encoding for multiple general transcription factors in neurodevelopmental disorders including autism suggested that alterations at the global level of gene expression regulation might also relate to disease risk in sporadic cases of autism. This premise can be tested by evaluating for global changes in the overall distribution of gene expression levels. For instance, in mice, we recently showed that variability in hippocampal-dependent behaviors was associated with variability in the pattern of the overall distribution of gene expression levels, as assessed by variance in the distribution of gene expression levels in the hippocampus. We hypothesized that a similar change in the variance in gene expression levels might be found in children with autism. Ge

ORGANISM(S): Homo sapiens

SUBMITTER: mark alter 

PROVIDER: E-GEOD-25507 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress