Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Effect of sigH in the growth phase transition of Clostridium difficile

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE25474: Comparison of the expression profiles of 630E strain after 4h and 10h of growth GSE25475: Comparison of the expression profiles of 630E strain and a sigH mutant after 10h of growth This study is based on two microarray datasets, in one hand a phase transition comparison using the expression profiles of 630E strain after 4h and 10h of growth. In other hand a comparison at 10h of growth between a mutant of the sigH gene and the WT strains. This experimental procedure was designed to investigate the effect of sigH in the growth phase transition of Clostridium difficile. Refer to individual Series

ORGANISM(S): [Clostridium] difficile

SUBMITTER: Monot Marc 

PROVIDER: E-GEOD-25521 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

The key sigma factor of transition phase, SigH, controls sporulation, metabolism, and virulence factor expression in Clostridium difficile.

Saujet Laure L   Monot Marc M   Dupuy Bruno B   Soutourina Olga O   Martin-Verstraete Isabelle I  

Journal of bacteriology 20110513 13

Toxin synthesis in Clostridium difficile increases as cells enter into stationary phase. We first compared the expression profiles of strain 630E during exponential growth and at the onset of stationary phase and showed that genes involved in sporulation, cellular division, and motility, as well as carbon and amino acid metabolism, were differentially expressed under these conditions. We inactivated the sigH gene, which encodes an alternative sigma factor involved in the transition to post-expon  ...[more]

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