MiRNA array after p63 knock down in human squamous cell carcinoma

ABSTRACT: A central challenge in human cancer therapy is the identification of pathways that control tumor cell survival and chemosensitivity in the absence of functional p53. The p53-related transcription factors p63 and p73 exhibit distinct, p53-independent roles in development and cancer: p73 promotes genome stability and mediates chemosensitivity, while p63 largely lacks these p53-like functions and instead promotes proliferation and cell survival. Here, we identify a new and physiologically important mechanism of p63/p73 cross-talk which governs the balance between pro-survival and pro-apoptotic programs in both human and murine squamous cell carcinoma. Through comprehensive profiling of p63-regulated microRNAs (miRs), we identified a subset which target p73 for inhibition, including miR-193a-5

ORGANISM(S): Homo sapiens

SUBMITTER: benjamin ory 

PROVIDER: E-GEOD-25524 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress