Alteration of peripheral blood monocyte gene expression in humans following diesel exhaust inhalation

ABSTRACT: Background: Epidemiologic associations between acutely increased cardiorespiratory morbidity and mortality and particulate air pollution are well-established, but the effects of acute pollution exposure on human gene expression changes are not well understood. Objectives: In order to identify potential mechanisms underlying epidemiologic associations between air pollution and morbidity, we explored changes in gene expression in humans following inhalation of fresh diesel exhaust (DE), a model for particulate air pollution. Methods: 14 ethnically homogeneous (white males), young, healthy subjects underwent sixty minute inhalation exposures on 2 separate days with clean air (CA) or freshly generated and diluted DE at a concentration of 300 μg/m3 PM2.5. Prior to and 24 hours following each

ORGANISM(S): Homo sapiens

SUBMITTER: Howard Kipen 

PROVIDER: E-GEOD-25531 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress