Cell Type-Specific DNA Methylation at Intragenic CpG Islands in the Immune System (gene expression data)

ABSTRACT: Human and mouse genomes contain a similar number of CpG islands (CGIs), which are discrete CpG-rich DNA sequences associated with transcription start sites. In both species, about 50% of all CGIs are remote from annotated promoters, but nevertheless often have promoter-like features. To document the role of CGI methylation in cell differentiation, we analysed DNA methylation at a comprehensive CGI set in cells of the mouse hematopoietic lineage. Using a method that potentially detects ~33% of genomic CpGs in the methylated state (>7 million) we found that large differences in gene expression were accompanied by surprisingly few DNA methylation changes. There were, however, many DNA methylation differences between hematopoietic cells and a distantly related tissue, brain. Altered DNA methyl

ORGANISM(S): Mus musculus

SUBMITTER: Adrian Bird 

PROVIDER: E-GEOD-25578 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress