The small RNA PhrS stimulates synthesis of the Pseudomonas aeruginosa quinolone signal

ABSTRACT: Quorum sensing, a cell-to-cell communication system based on small signal molecules, is employed by the human pathogen Pseudomonas aeruginosa to regulate virulence and biofilm development. Moreover, regulation by small trans-encoded RNAs has become a focal issue in virulence gene expression of bacterial pathogens. In this study, we have identified the small RNA PhrS as an activator of PqsR synthesis, one of the key quorum sensing regulators in P. aeruginosa. Genetic studies revealed a novel mode of regulation by a sRNA, whereby PhrS uses a base-pairing mechanism to activate a short upstream open reading frame to which the pqsR gene is translationally coupled. Expression of phrS is induced by the oxygen-responsive regulator ANR when the oxygen supply decreases. Thus, PhrS is the first bact

ORGANISM(S): Pseudomonas aeruginosa

SUBMITTER: Sylvain Pradervand 

PROVIDER: E-GEOD-25595 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress