Bone marrows infiltrating human neuroblastoma cells express high levels of calprotectin and HLA-G proteins.

ABSTRACT: In neuroblastoma (NB) patients metastasis are the main cause of death, thus understanding the biological and genetic features of the metastatic NB cells is needed to reach efficient target-based therapies for high risk patients. In recent years, several prognostic signatures derived from gene expression profiles, DNA abnormalities, and non-coding RNAs have been proposed as sensitive indicators of tumor aggressiveness in NB patients. Although efforts have been performed in order to validate each gene classifier on independent patient cohorts, the major challenge remains to identify specific signature of in vivo metastatic NB cells. Based on the above considerations, we evaluated the gene expression profile of the bone-marrow (BM) infiltrating metastatic NB cells in comparison with that of p

ORGANISM(S): Homo sapiens

SUBMITTER: PAOLA SCARUFFI 

PROVIDER: E-GEOD-25623 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress