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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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MiRNA combined

ABSTRACT: miRNA expression data for the "MicroRNA expression profiles classify human cancers". Keywords = miRNA Keywords = microRNA Keywords = normal Keywords = tumor Keywords = cell-line Keywords = cancer Keywords: other

ORGANISM(S): Mus musculus

SUBMITTER: H Horvitz

PROVIDER: E-GEOD-2564 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

MicroRNA expression profiles classify human cancers.

Lu Jun J Getz Gad G Miska Eric A EA Alvarez-Saavedra Ezequiel E Lamb Justin J Peck David D Sweet-Cordero Alejandro A Ebert Benjamin L BL Mak Raymond H RH Ferrando Adolfo A AA Downing James R JR Jacks Tyler T Horvitz H Robert HR Golub Todd R TR

Nature 20050601 7043

Recent work has revealed the existence of a class of small non-coding RNA species, known as microRNAs (miRNAs), which have critical functions across various biological processes. Here we use a new, bead-based flow cytometric miRNA expression profiling method to present a systematic expression analysis of 217 mammalian miRNAs from 334 samples, including multiple human cancers. The miRNA profiles are surprisingly informative, reflecting the developmental lineage and differentiation state of the tu ...[more]

PMID: 15944708

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MicroRNA expression profiling of human breast cancer identifies new markers of tumour subtype

Project description:MicroRNAs (miRNAs), a class of short non-coding RNAs, often act post-transcriptionally to inhibit gene expression. We used a bead-based flow cytometric profiling method to obtain miRNA expression data for 93 primary human breast tumours, 21 cell lines and five normal breast samples. Of 309 human miRNAs assayed we identify 133 miRNAs expressed in human breast and breast tumours. We used mRNA expression profiling to classify the breast tumours into Luminal A, Luminal B, Basal-like, HER2+/ER- and Normal-like. A number of miRNAs are differentially expressed between these molecular tumour subtypes and individual miRNAs are associated with clinicopathological factors. Furthermore, we find that miRNAs could classify basal versus luminal tumour subtypes in an independent data set. Keywords = miRNA Keywords = microRNA Keywords = normal Keywords = tumour Keywords = cell line Keywords = breast Keywords = cancer Keywords: Bead-based flow cytometric profiling miRNA expression data for 93 primary human breast tumours, 21 cell lines and five normal breast samples

2007-10-09 | E-GEOD-7842 | biostudies-arrayexpress

megamiR, microRNA expression profiles during megakaryocyte-erythrocyte progenitor (MEP) differentiation

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