Identification and functional analysis of novel genes expressed in the Anterior Visceral Endoderm

ABSTRACT: During early development, the correct establishment of the body axes is a critical step. The anterior pole of the mouse embryo is established when Distal Visceral Endoderm (DVE) cells migrate to form the Anterior Visceral Endoderm (AVE). Asymmetrical expression of Lefty1, Cerl and Dkk determines the direction of DVE migration and the future anterior side. Besides being implicated in the establishment of Anterior-Posterior axis the AVE has also been correlated with anterior neural specification. In order to better understand the role of the AVE in these processes, this cell population was isolated using a cerlP-EGFP transgenic mouse line, and a differential screening was performed using Affymetrix GeneChip technology. From this differential screening, 175 genes were found to be upregulated

ORGANISM(S): Mus musculus

SUBMITTER: Lisa Goncalves 

PROVIDER: E-GEOD-25675 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress