Gene expression profile of calcium mediated prevention of colorectal cancer in a mouse model

ABSTRACT: To further elucidate the mechanism of calcium mediated chemoprevention of colorectal cancer,we have employed whole genome microarray expression profiling as a discovery platform to identify genes that differentially expressed in mice from high calcium group compared those from DMH group.The mice of DMH group were received normal diet (calcium concentration,1.24%) and subcutaneous injection of 1,2-Dimethylhydrazine at a dose of 20 mg/kg once weekly for 20 weeks,the mice of high calcium group were received high calcium diet(calcium concentration,3%) and subcutaneous injection of 1,2-Dimethylhydrazine at a dose of 20 mg/kg once weekly for 20 weeks.The mice were sarcrificed at 24 week.Nine normal colonic mucosa (3 from DMH group, 3 from high calcium group mice with tumors, and 3 from high calc

ORGANISM(S): Mus musculus

SUBMITTER: Jing-Yuan Fang 

PROVIDER: E-GEOD-25680 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress