Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Adrian Bird
PROVIDER: E-GEOD-25688 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Genome research 20110531 7
Human and mouse genomes contain a similar number of CpG islands (CGIs), which are discrete CpG-rich DNA sequences associated with transcription start sites. In both species, ∼50% of all CGIs are remote from annotated promoters but, nevertheless, often have promoter-like features. To determine the role of CGI methylation in cell differentiation, we analyzed DNA methylation at a comprehensive CGI set in cells of the mouse hematopoietic lineage. Using a method that potentially detects ∼33% of genom ...[more]