Genome-wide microarray analysis of normal human fibroblasts in response to γ-radiation and the radiation induced bystander effect

ABSTRACT: The bystander effect from ionizing radiation consists of cellular responses generated from non-irradiated cells to the irradiation of their neighbors. The bystander effect is predominant at low doses and can lead to DNA damage and genomic instability in the affected cells. This non-targeted effect of radiation has received attention due to its potential implications for cancer therapy and radiation protection. Although studied extensively, a complete understanding of its molecular mechanism is the subject of ongoing research. While many studies have targeted specific factors which are suggested to be involved in the bystander effect, few have looked at whole genome gene expression in bystander cells. Furthermore, even fewer studies have looked at the expression in normal human cell lines.

ORGANISM(S): Homo sapiens

SUBMITTER: Erta kalanxhi 

PROVIDER: E-GEOD-25772 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress