Genome-wide analysis of Tdrd7 knockdown in lens epithelial-derived cell line 21EM15

ABSTRACT: Analysis of Tdrd7 deficiency in mouse lens epithelial-derived cell line at gene expression level. The hypothesis tested was that Tdrd7 is involved in post-transcriptional control of gene expression in the lens. Results provide evidence for differential regulation of genes involved in lens homeostasis and cataract formation in the absence of Tdrd7. In eukaryotic cells, cytoplasmic RNA granules (RGs) function in the post-transcriptional control of gene expression. However, the involvement of RGs and their component proteins in vertebrate organogenesis is unknown. We report two independent cases of pediatric cataract with loss-of-function mutations in TDRD7, which encodes a Tudor domain RNA binding protein. TDRD7 deficiency in chick lens produces cataracts, and Tdrd7 null mouse mutants dev

ORGANISM(S): Mus musculus

SUBMITTER: Anton Aboukhalil 

PROVIDER: E-GEOD-25774 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress