Unknown,Transcriptomics,Genomics,Proteomics

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Genome-wide maps of CTCF in R1/E embryonic stem cells


ABSTRACT: ChIP-seq based determination of CTCF binding sites in embryonic stem cells (ESC) Examination of CTCF binding sites

ORGANISM(S): Mus musculus

SUBMITTER: Maciej Paszkowski-Rogacz 

PROVIDER: E-GEOD-25777 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


For self-renewal, embryonic stem cells (ESCs) require the expression of specific transcription factors accompanied by a particular chromosome organization to maintain a balance between pluripotency and the capacity for rapid differentiation. However, how transcriptional regulation is linked to chromosome organization in ESCs is not well understood. Here we show that the cohesin component RAD21 exhibits a functional role in maintaining ESC identity through association with the pluripotency transc  ...[more]

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