Genome profiling of mouse pulmonary epithelial type II cells

ABSTRACT: Pulmonary alveoli contain two distinct populations of epithelial cells. Type II cells produce pulmonary surfactant lipids and surfactant-associated proteins (SP) required for maintaining alveolar surface tension at the air-liquid interface and host defense against respiratory pathogens. Type II cells are also progenitors for epithelial type I cells, a terminally differentiated elongated cell that covers microvascular endothelial cells and participates in gas exchange. Despite some indirect evidence, it is unknown whether subpopulations of type II cells exist. We created a line of transgenic mice expressing enhanced green fluorescent protein (EGFP) under control of the human SP-C promoter. Expression of EGFP may define a subpopulation of type II cells because it is 1) expressed in ap

ORGANISM(S): Mus musculus

SUBMITTER: Stephen Welle 

PROVIDER: E-GEOD-25778 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress