Unknown,Transcriptomics,Genomics,Proteomics

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Global microRNA expression profiling of microdissected tissues from diseased and non-diseased pancreatic tissues


ABSTRACT: Global microRNA expression profiling of microdissected pancreatic tissues were collected using Agilent miRNA microarrays (G4470B, Sanger 10.1) carrying 723 individual human miRNA probes. Four different sources of RNA were analyzed: microdissected normal pancreatic ductal cells (ND, n=4),microdissected acinar cells (AC, n=4), macrodissected chronic pancreatitis (CP, n=5) and micordissected xenograft tissues derived from primary pancreatic ductal adenocarcinomas (PDAC, n=5). Four condition (AZ, ND, PDAC, CP), each condition is represented by 4 to 5 biological replicates

ORGANISM(S): Homo sapiens

SUBMITTER: Stephan Hahn 

PROVIDER: E-GEOD-25820 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Global microRNA expression profiling of microdissected tissues identifies miR-135b as a novel biomarker for pancreatic ductal adenocarcinoma.

Munding Johanna B JB   Adai Alex T AT   Maghnouj Abdelouahid A   Urbanik Aleksandra A   Zöllner Hannah H   Liffers Sven T ST   Chromik Ansgar M AM   Uhl Waldemar W   Szafranska-Schwarzbach Anna E AE   Tannapfel Andrea A   Hahn Stephan A SA  

International journal of cancer 20111119 2


Pancreatic ductal adenocarcinoma (PDAC) is known for its poor prognosis resulting from being diagnosed at an advanced stage. Accurate early diagnosis and new therapeutic modalities are therefore urgently needed. MicroRNAs (miRNAs), considered a new class of biomarkers and therapeutic targets, may be able to fulfill those needs. Combining tissue microdissection with global miRNA array analyses, cell type-specific miRNA expression profiles were generated for normal pancreatic ductal cells, acinar  ...[more]

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