Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

DNA methylation represents one of the key regulator that transcriptional control of highly expressed genes in gastric cancer.

ABSTRACT: We used microarray approach to establish demethylated specific genes profiles in early gastric cancer. We analyzed 11 gastric cancer cell lines and 32 pairs of gastric cancer and normal samples to discover methylation signatures specific to gastric cancer cells.

ORGANISM(S): Homo sapiens

SUBMITTER: Han-Chul Lee

PROVIDER: E-GEOD-25869 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Aberrant up-regulation of LAMB3 and LAMC2 by promoter demethylation in gastric cancer.

Kwon Oh-Hyung OH Park Jong-Lyul JL Kim Mirang M Kim Jeong-Hwan JH Lee Han-Chul HC Kim Hee-Jin HJ Noh Seung-Moo SM Song Kyu-Sang KS Yoo Hyang-Sook HS Paik Sang-Gi SG Kim Seon-Young SY Kim Yong Sung YS

Biochemical and biophysical research communications 20110221 4

The LAMB3 and LAMC2 genes encode the laminin-5 β3 and γ2 chains, respectively, which are parts of laminin-5, one of the major components of the basement membrane zone. Here, we report the frequent up-regulation of LAMB3 and LAMC2 by promoter demethylation in gastric cancer. Gene expression data analysis showed that LAMB3 and LAMC2 were up-regulated in various tumor tissues. Combined analyses of DNA methylation and gene expression of both genes in gastric cancer cell lines and tissues showed that ...[more]

PMID: 21345334

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Dataset Information

DNA methylation represents one of the key regulator that transcriptional control of highly expressed genes in gastric cancer.

Publications

Aberrant up-regulation of LAMB3 and LAMC2 by promoter demethylation in gastric cancer.

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