Artemisinin resistance in Plasmodium falciparum is associated with an altered temporal pattern of transcription (expression)

ABSTRACT: Artemisinin resistance in Plasmodium falciparum malaria has emerged in western Cambodia. This is a major threat to global plans to control and eliminate malaria as the artemisinins are a key component of antimalarial treatment throughout the world. Using DNA microarrays we identify key features of a transcriptional profile that are associated with the delayed parasite clearance phenotype. These include reduced expression of several basic metabolic and cellular pathways in the early stages, and increased expression of essentially all functionalities associated with protein metabolism in the later stages of P. falciparum intraerythrocytic development. This is consistent with the reduced ring stage susceptibility that characterizes artemisinin resistant P. falciparum. This modulation of

ORGANISM(S): Plasmodium falciparum

SUBMITTER: Sachel Mok 

PROVIDER: E-GEOD-25878 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress