Comparative transcriptome profiling of Amyloid Precursor Protein APP family members in the adult cortex

ABSTRACT: The β-amyloid precursor protein APP and the related APLPs, undergo complex proteolytic processing giving rise to several fragments. Whereas it is well established that Aβ accumulation is a central trigger for Alzheimer disease (AD), the physiological role of APP family members and their diverse proteolytic products is still largely unknown. The secreted APPsα ectodomain has been shown to be involved in neuroprotection and synaptic plasticity. The γ-secretase generated APP intracellular domain AICD, functions as a transciptional regulator in heterologous reporter assays, although its role for endogenous gene regulation has remained controversial. To gain further insight into the molecular changes associated with knockout phenotypes and to elucidate the physiological functions of APP fa

ORGANISM(S): Mus musculus

SUBMITTER: Ulrike Müller 

PROVIDER: E-GEOD-25926 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress