MicroRNA epxression patterns can discriminate between patients with oligometastatic and polymetastatic progression: cell lines

ABSTRACT: Cancer staging and treatment frequently assume a binary division of tumors into localized or metastatic cancers. We proposed a state of metastatic disease defined by the number of metastases termed oligometastases. Patients with oligometastatic disease may be cured with localized methods of cancer treatment. We analyzed miRNA expression from paraffin blocks of primary or metastatic tumor samples derived from oligometastatic (? 5 metastases) patients treated with high dose localized radiotherapy. We report patterns of miRNA expression in the metastatic and primary tumor samples that identify patients who failed to progress to widespread polymetastases. We created a model of oligometastases of human tumors in immune compromised mice. The miRNA patterns of gene expression derived from pati

ORGANISM(S): Homo sapiens

SUBMITTER: Yong Huang 

PROVIDER: E-GEOD-25967 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress