Eighteen hours monoclonal antibody C7 exposure

ABSTRACT: We have developed a monoclonal antibody (mAb) C7 that reacts with Als3p and enolase present in Candida albicans cell wall and exerts three anti-Candida activities: candidacidal activity and inhibition of both adhesion and filamentation. To investigate the mode of action of mAb C7 on fungal viability, we examined changes in the genome-wide gene expression profile of C. albicans grown in presence of a subinhibitory concentration of mAb C7 (12.5 µg/ml) by using microarrays. A total of 49 genes were found to be differentially expressed upon treatment with mAb C7. Of these, 28 were found to be up-regulated and 21 down-regulated. The categories of up-regulated genes with the largest number of variations were those involved in iron uptake or related to iron homeostasis (42.86%), while the energy-

ORGANISM(S): Candida albicans

SUBMITTER: Iñigo Fernandez de Larrinoa 

PROVIDER: E-GEOD-25969 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress