Microarray gene expression data from Hdh knock-out, wild-type and knock-in embryonic stem cells

ABSTRACT: Huntington's disease (HD) features a unique disease-initiating mechanism hypothesized to entail an impact of the CAG repeat encoded polyglutamine region on the full-length huntingtin protein, with dominant effects that are continuous with CAG size, in a simple gain of function. To evaluate these predictions, we generated a series of heterozygous Hdh CAG knock-in mouse embryonic stem (ES) cell lines, with 18, 48, 89, 109 CAGs, and found that a continuous analytic strategy efficiently identified, from genome-wide datasets, 73 genes and 172 pathways whose expression varied continuously with CAG length. The CAG-correlated genes were distinct from the set of 754 genes that distinguished huntingtin null ES cells from wild-type controls, and CAG-correlated pathways did not display a one-to-one co

ORGANISM(S): Mus musculus

SUBMITTER: Jong-Min Lee 

PROVIDER: E-GEOD-26001 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress