DNA methylation profiling reveals novel biomarkers and important roles for DNA methyltransferases in prostate cancer

ABSTRACT: Genome wide DNA methylation profiling of normal and tumor prostate samples, as well as cultured primary prostate cells overexpressing DNA Methyltransferases (DNMTs) and EZH2 Candidate gene based studies have identified a handful of aberrant CpG DNA methylation events in prostate cancer. However, DNA methylation profiles have not been compared on a large scale between prostate tumor and normal prostate, and the mechanisms behind these alterations are unknown. In this study, we quantitatively profiled 95 primary prostate tumors and 86 healthy prostate tissue samples for their DNA methylation levels at 26,333 CpGs representing 14,104 gene promoters by using the Illumina HumanMethylation27 platform. A 2-class Significance Analysis of this dataset revealed 5,912 CpG sites with increased DNA met

ORGANISM(S): Homo sapiens

SUBMITTER: Yuya Kobayashi 

PROVIDER: E-GEOD-26126 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress