Expression data from MTDH knockdown in the Hec50co endometrial cancer cell line

ABSTRACT: Understanding the molecular underpinnings of chemoresistance is vital to design therapies to restore chemosensitivity. In particular, metadherin (MTDH) has been demonstrated to have a critical role in chemoresistance. Over-expression of MTDH has recently been implicated in poor clinical outcome in breast cancer, neroblastoma, hepatocellular carcinoma and prostate cancer. In this present study, we focused on the therapeutic benefit of MTDH depletion to restore sensitivity to cell death mediated by a combinatorial therapy of tumor necrosis factor-alpha-related apoptosis-inducing ligand (TRAIL), which promotes death of cancerous cells of the human reproductive tract, and histone deacetylase (HDAC) inhibitors, which have been shown to increase sensitivity of cancer cells to TRAIL-induced apopt

ORGANISM(S): Homo sapiens

SUBMITTER: Pavla Brachova 

PROVIDER: E-GEOD-26134 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress