Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Eric Pierce
PROVIDER: E-GEOD-26248 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Bioinformatics (Oxford, England) 20110719 18
<h4>Motivation</h4>A critical task in high-throughput sequencing is aligning millions of short reads to a reference genome. Alignment is especially complicated for RNA sequencing (RNA-Seq) because of RNA splicing. A number of RNA-Seq algorithms are available, and claim to align reads with high accuracy and efficiency while detecting splice junctions. RNA-Seq data are discrete in nature; therefore, with reasonable gene models and comparative metrics RNA-Seq data can be simulated to sufficient acc ...[more]