Gene expression signatures differ with extent of atherosclerosis in monkey iliac artery

ABSTRACT: Goal of the experiment: To examine differential gene expression in the iliac arteries of cynomolgous monkeys in the presence of small, medium, or large atherosclerotic plaque. Brief description of the experiment: Objective: To examine global gene expression patterns in the iliac arteries of monkeys containing small, medium, or large atherosclerotic plaque. Design: The left iliac artery of 12 ovariectomized cynomolgous monkeys on a high fat diet for 8 years was biopsied. Gene expression was analyzed by DNA microarray and real time RT-PCR. Results: Significant up- or down-regulation of 986 genes was observed in monkey iliac arteries in the presence of atherosclerotic plaque. Changes in gene expression with atherosclerosis ranged from 0.1-151.9-fold. Differentially expressed genes i

ORGANISM(S): Macaca fascicularis

SUBMITTER: Kathleen Eyster 

PROVIDER: E-GEOD-26326 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress