The gene expression response of MCF7 and MDAMB231 to glutamine deprivation

ABSTRACT: There are two major subtype of cells in breast cancer. These cancer cells response differently to glutamine deprivation, here we use one luminal type of breast cancer cell (MCF7) and one basal type of breast cancer cell (MDAMB231) to compare the gene expression differences of these two types of cancer cells in glutamine deprivation. Many cancer cells depend on glutamine for survival and oncogenic transformation. Although targeting glutamine metabolism is proposed as novel therapies, their heterogeneity among different tumors is unknown. Here, we found only basal-type, but not luminal-type breast cancer cells, exhibited phenotypes of glutamine dependency and may benefit from glutamine-targeting therapeutics. The glutamine independence of luminal-type cells is caused by the specific expressi

ORGANISM(S): Homo sapiens

SUBMITTER: Hsiu-Ni Kung 

PROVIDER: E-GEOD-26370 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress