Losses of chromosome 5q and 14q mark a subset of gastric cancers with good clinical outcome

ABSTRACT: Purpose: To improve clinical outcome of gastric cancer patients, most emphasis is on improving therapeutic regimens, including more extensive surgery as well as (neo)adjuvant chemotherapy. The present study set out to identify, based on DNA copy number profiling, subgroups of patients with different clinical outcomes who thus would qualify for different therapy intensities. Experimental Design: DNA of 206 gastric cancer patients was isolated and analyzed by genome wide array comparative genomic hybridization. DNA copy number profiles were evaluated and correlated to lymph node status and survival. In addition, HSP90 protein expression was analyzed and correlated to survival in 290 gastric cancer patients. Results: Frequent (>20%) DNA copy number gains were observed on chromosomes 1p, 6p,

ORGANISM(S): Homo sapiens

SUBMITTER: Oscar Krijgsman 

PROVIDER: E-GEOD-26389 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress