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Transcription profiling of right lungs from C57BL/6J, A/J and C3H/HeJ mice following bleomcyin exposure to characterize strain dependent pulmonary bleomycin response.

ABSTRACT: right lung gene expression of C57BL/6J, A/J and C3H/HeJ mice following bleomcyin exposure. Keywords = mouse, lung, bleomycin, strain differences

ORGANISM(S): Mus musculus

SUBMITTER: Christina Kathleen Haston

PROVIDER: E-GEOD-2640 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Murine candidate bleomycin induced pulmonary fibrosis susceptibility genes identified by gene expression and sequence analysis of linkage regions.

Haston C K CK Tomko T G TG Godin N N Kerckhoff L L Hallett M T MT

Journal of medical genetics 20050601 6

<h4>Background</h4>Pulmonary fibrosis is a complex disease for which the predisposing genetic variants remain unknown. In a prior study, susceptibility to bleomycin induced pulmonary fibrosis was mapped to loci Blmpf1 and Blmpf2 on chromosomes 17 and 11, respectively, in a C57BL/6J (B6, susceptible) and C3Hf/KAM (C3H, resistant) mouse cross.<h4>Methods</h4>Herein, the genetic basis of bleomycin induced pulmonary fibrosis was investigated in an approach combining gene expression and sequencing da ...[more]

PMID: 15937080

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