Gene networks associated with conditional fear in mice identified using a systems genetics approach

ABSTRACT: To uncover genetic networks governing the biology of conditional fear, we used a systems genetics approach to analyze a hybrid mouse diversity panel (HMDP) with high mapping resolution. By integrating fear phenotypes, transcript profiling data from hippocampus and striatum and genotype information, two gene co-expression networks correlated with context-dependent immobility were identified. We prioritized the key markers and genes in these pathways using intramodular connectivity measures and structural equation modeling. We mapped 27 behavioral quantitative trait loci with a false discovery rate of 5%. We also identified two gene co-expression networks correlated with context-dependent immobility. Highly connected genes in the context fear modules included Psmd6, Ube2a and Usp33, sugg

ORGANISM(S): Mus musculus

SUBMITTER: Christopher Park 

PROVIDER: E-GEOD-26500 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress