Involvement of the TGF-β and β-catenin pathways in pelvic lymph node metastasis in early stage cervical cancer

ABSTRACT: Purpose: Presence of pelvic lymph node metastases is the main prognostic factor in early stage cervical cancer patients, primarily treated with surgery. Aim of this study was to identify cellular tumor pathways associated with pelvic lymph node metastasis in early stage cervical cancer. Experimental Design: Gene expression profiles (Affymetrix U133 plus 2.0) of 20 patients with negative (N0) and 19 with positive lymph nodes (N+), were compared with gene sets that represent all 285 presently available pathway signatures. Validation immunostaining of tumors of 274 consecutive early stage cervical cancer patients was performed for representatives of the identified pathways. Results: Analysis of 285 pathways resulted in identification of five pathways (TGF-β, NFAT, ALK, BAD, and PAR1) that wer

ORGANISM(S): Homo sapiens

SUBMITTER: Maartje Noordhuis 

PROVIDER: E-GEOD-26511 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress