Targets of Ephrin-A signaling in epidermal keratinocytes

ABSTRACT: Both ephrins and their receptors are membrane bound, restricting their interactions to the sites of direct cell-to-cell interfaces. They are widely expressed, often co-expressed and regulate developmental processes, cell adhesion, motility, survival, proliferation, and differentiation. Both tumor suppressor and oncogene activities are ascribed to EFNs and Ephs in various contexts. A major conundrum regarding the EFN/Eph system concerns their large number and functional redundancy, given the promiscuous cross-activation of ligands and receptors and the overlapping intracellular signaling pathways. To address this issue, we treated human epidermal keratinocytes with 5 EFNAs individually and defined the transcriptional responses in the cells. We found that a large set of genes is coregulated

ORGANISM(S): Homo sapiens

SUBMITTER: Miki Blumenberg 

PROVIDER: E-GEOD-26521 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress