The cold-induced two-component system CBO0366/CBO0365 regulates metabolic pathways with novel roles in cold tolerance of Group I Clostridium botulinum ATCC 3502

ABSTRACT: The two-component system CBO0366/CBO0365 was recently demonstrated to have a role in cold tolerance of Group I Clostridium botulinum ATCC 3502. The mechanisms under its control, ultimately resulting in increased sensitivity to low temperature, are unknown. A transcriptomic analysis with DNA microarrays was performed to identify the differences in global gene expression patterns of the wild-type ATCC 3502 and a derivative mutant with insertionally inactivated cbo0365 at 37 M-BM-0C and 15 M-BM-0C. Altogether 150 or 141 chromosomal CDSs were found to be differently expressed in the cbo0365 mutant at 37 M-BM-0C or 15 M-BM-0C, respectively, and thus considered to be under direct or indirect transcriptional control of the response regulator CBO0365. Of the differentially-expressed CDSs, expressi

ORGANISM(S): Clostridium botulinum A str. ATCC 3502

SUBMITTER: Elias Dahlsten 

PROVIDER: E-GEOD-26587 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress